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Colistin sulfate (also known as colimycin sulfate, colistin sulfate, Klebisin, polymyxin E, etc.) has the following notable characteristics:

I. Physical and Chemical Properties

·Appearance: The pure product is a white or off-white powder, while the premix appears as light brown or brown granules or powder.

·Solubility: It is easily soluble in water but poorly soluble in ether, acetone, or chloroform, and slightly soluble in methanol and ethanol.

·Stability: It is stable within a pH range of 3 to 7.5, with the best stability in solutions where the pH does not exceed 7.5, ensuring consistent efficacy. However, it is unstable in highly alkaline solutions.

·Heat Resistance: Colistin sulfate has good heat resistance.
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